戴家銀(Dai Jiayin)
特聘教授
電子郵件🏂：daijy65@sjtu.edu.cn
研究方向
1. 新型汙染物的高通量檢測與識別
2. 新型汙染物的人體暴露特征與健康效應
3. 新型汙染物的毒性效應及分子機製
4. 基於毒性規律指導化學品綠色替代與合成
研究領域包括環境分析、環境健康與毒理學👋🏼，鼓勵多學科交叉研究，歡迎具有環境科學🥧、分子生物學、組學與生物信息學🧘🏻♀️❣️、分析化學等專業背景的同學參加本科生科研，攻讀碩士、博士學位🪄👳🏻♂️。
個人簡歷
1996年－1999年 南京大學環境意昂4，獲博士學位
1999年－2000年 同濟大學意昂4体育平台🚴🏼♀️，博士後
2000年－2001年，美國德克薩斯州立大學加爾韋斯頓醫學分校，博士後
2001年－2005年，美國康奈爾大學醫意昂4，生物化學系，博士後
2005年－2020年，中國科意昂4動物研究所♥︎，中國科意昂4動物生態與保護生物學重點實驗室👩🔬，主任，研究員
2020年－至今，意昂4体育平台🤳🏼🦻，特聘教授
國家傑出青年基金獲得者（2010年）🕴，中科院"Bairen計劃"入選者（2005年🏃➡️，終期評估優秀），美國化學會（ACS）Chemical Research in Toxicology雜誌副主編（2018年1月-至今）。中國毒理學會環境與生態毒理學專業委員會 常務委員（第一~三屆）💂🏼♂️；中國環境學會環境風險專業委員會 委員（2012年1月-至今）✡️；中國環境科學學會持久性有機汙染物專業委員會 委員（2012年1月-至今）；中國毒理學會計算毒理專業委員會委員（第一屆-至今）；中華預防醫學會環境衛生分會常務委員（第八屆）。中國科意昂4城市環境研究所城市環境健康重點實驗室 學術委員會委員（2013年1月-至今）🏚；安徽省濕地生態保護與修復重點實驗室 學術委員會委員（2018年-至今）🧕🏽。
先後主持或參加國家自然科學傑出青年基金項目👱♀️、重點項目、重大國際合作項目、面上項目、973項目和重點研發計劃的課題、中科院知識創新工程重要方向性項目🕴🏼、中科院戰略先導B項目的課題等19項👐。2004年以來在Cell, Environmental Health Perspectives, Molecular Cellular Proteomics, Environmental Sciences & Technology等重要SCI刊物發表論文127篇（其中第一作者或通訊作者99篇），他引3471次，H因子35。培養的研究生多人次先後獲中國科意昂4優秀博士論文🩳、中國科意昂4院長優秀獎🧓🏿、朱李月華獎學金、地奧獎學金（一等和二等）、5人次獲國家獎學金（博士研究生4人和碩士研究生1人）。
科研成果
代表性科研項目（10項）
1. 國家自然科學基金委重點項目（21737004）🏋🏿♂️，基於系統性毒性研究指導全氟烷基化合物替代品設計與綠色合成，2018/01-2022/12，300萬，主持
2. 國家重點研發計劃生殖專項，課題二（2018YFC1004202）🏊♀️，男性不育的環境-基因交互作用研究，2018/12-2021/12🥬，188萬（987萬）👭，參加
3 國家自然科學基金委面上項目（21876173），全氟烷基化合物替代品影響斑馬魚魚鰾發育的分子機製研究，2019/01-2022/12🌅，66萬，主持
4. 國家重點研發計劃食品專項，課題五（2017YFC1600205），食品中典型持久性有機汙染物健康危害與毒性機製，2017/01-2021/12⚒，300萬🤔，課題負責人
5. 國家自然科學基金委面上項目（21377128），全氟類化合物與人類肝臟型脂肪酸結合蛋白的相互作用及毒性機製研究，2014/01-2017/12，88萬，主持
6. 國家自然科學基金國際(地區)合作與交流項目（31320103915），野生動物體內全氟烷基化合物的來源🤴🏽、存在狀態及毒性機製研究，2014/1-2018/12📩，274萬，主持
7. 中科院先導B專項，項目四課題二子課題二（XDB14040202）🧘🏿♀️，典型汙染物引發機體糖和脂肪代謝紊亂的機製，2014/07-2019/06💁🏼♀️👉🏿，421萬，子課題負責人
8. 國家重點基礎研究發展計劃（973計劃）⬇️，課題四（2013CB945204）🦸🏿，血脂紊亂影響精子發生的生物標記物的鑒定和臨床幹預🫃🏽，2013/01-2017/08，556萬，課題負責人
9. 國家自然科學基金委傑出青年基金項目（31025006）🔬，持久性有機汙染物的生態毒理機製，2011/01-2014/12，200萬元👩🏻🔬，主持
10. 國家自然科學基金委重點項目（20837004），典型全氟有機汙染物的水環境過程及生態毒理機製研究🏋🏼，2009/01-2012/12，200萬元，主持
近五年代表性論文（30篇）
(1) Yao Jingzhi, Pan Yitao, Sheng Nan, Su Zhaoben, Guo Yong, Wang Jianshe, Dai, Jiayin(*), Novel perfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs): Occurrence and association with serum biochemical parameters in residents living near a fluorochemical plant in China, Environmental Science & Technology, 2020, 54 (21): 13389-13398
(2) Wang Jinghua, Pan Yitao, Wei Xiaofei, Dai, Jiayin(*), Temporal Trends in Prenatal Exposure (1998-2018) to Emerging and Legacy Per- and Polyfluoroalkyl Substances (PFASs) in Cord Plasma from the Beijing Cord Blood Bank, China, Environmental Science & Technology, 2020, 54 (20): 12850-12859
(3) Cui Qianqian, Pan Yitao, Wang Jinghua, Liu Hongxiu, Yao Bing, Dai, Jiayin(*), Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones, Environmental Pollution, 2020, 266 (2): 115330
(4) Liu Hongxiu(#), Pan Yitao(#), Jin Shuna; Sun Xiaojie, Jiang Yangqian, Wang Yuyan, Ghassabian Akhgar, Li Yuanyuan, Xia Wei, Cui Qianqian, Zhang Bin, Zhou Aifen, Dai Jiyin(*), Xu Shunqing(*). Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China. Journal of hazardous materials, 2020, 124378
(5) Liu Hongxiu(#), Pan Yitao(#), Jin Shuna, Li Yuanyuan, Zhao Liuqing, Sun Xiaojie, Cui Qianqian, Zhang bin, Zheng Tongzhang, Xia Wei, Zhou Aifen, Campana Anna Maria, Dai Jiyin(*), Xu Shunqing(*). Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns, Environment International, 2020, 140: 105636
(6) Pan, Yitao, Wang, Jinghua, Yeung, L. W. Y., Wei, Si, Dai, Jiayin(*), Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues, Trends in Analytical Chemistry, 2020, 124: 115481
(7) Wang, Jinxing(#), Shi Guohui(#), Yao Jingzhi, Sheng Nan, Cui, Ruina, Su Zhaoben, Guo, Yong, Dai, Jiayin(*), Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption, Environment International, 2020, 134: 105317
(8) Pan, Yitao, Cui, Qianqian, Wang, Jinghua, Sheng Nan, Jing, Jun, Yao, Bing(*), Dai, Jiayin(*), Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality, Environmental Health Perspectives, 2019, 127 (12): 127005
(9) Cui, Qianqian(#), Shi, Fanglei(#), Pan, Yitao, Zhang, Hongxia, Dai, Jiayin(*), Per- and polyfluoroalkyl substances (PFASs) in the blood of two colobine monkey species from China: Occurrence and exposure pathways, Science of the Total Environment, 2019, 674: 524-531
(10) Guo, Hua, Wang, Jinghua, Yao, Jingzhi, Sun, Sujie, Sheng, Nan, Zhang, Xiaowen, Guo, Xuejiang, Guo, Yong, Sun, Yan, Dai, Jiayin(*), Comparative hepatotoxicity of novel PFOA alternatives (perfluoropolyether carboxylic acids) on Male Mice, Environmental Science & Technology, 2019, 53 (7): 3929-3937
(11) Shi, Guohui, Cui, Qianqian, Wang, Jinxing, Guo, Hua, Pan, Yitao, Sheng, Nan, Guo, Yong, Dai, Jiayin(*), Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring, Environmental Pollution, 2019, 249: 550-559
(12) Shi, Guohui, Wang, Jinxing, Guo, Hua, Sheng, Nan, Cui, Qianqian, Pan, Yitao, Guo, Yong, Sun, Yan, Dai, Jiayin(*), Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish, Science of the Total Environment, 2019, 665: 855-863
(13) Sun, Sujie, Guo, Hua, Wang, Jianshe(*), Dai, Jiayin, Hepatotoxicity of perfluorooctanoic acid and two emerging alternatives based on a 3D spheroid model, Environmental Pollution, 2019, 246: 955-962
(14) Cui, Ruina, Li, Chenyang, Wang, Jianshe(*), Dai, Jiayin, Induction of hepatic miR-34a by perfluorooctanoic acid regulates metabolism-related genes in mice, Environmental Pollution, 2019, 244: 270-278
(15) Wang, Jinghua(#), Pan, Yitao(#), Cui, Qianqian, Yao, Bing, Wang, Jianshe(*), Dai, Jiayin, Penetration of PFASs across the Blood Cerebrospinal Fluid Barrier and Its Determinants in Humans, Environmental Science & Technology, 2018, 52 (22): 13553-13561
(16) Sun, Sujie, Wang, Jianshe(*), Lu, Yin, Dai, Jiayin, Corticosteroid-Binding Globulin, Induced in Testicular Leydig Cells by Perfluorooctanoic Acid, Promotes Steroid Hormone Synthesis, Archives of Toxicology, 2018, 92 (6): 2013-2025
(17) Zhou, Xiujuan, Wang, Jianshe(*), Sheng, Nan, Cui, Ruina, Deng, Yiqun, Dai, Jiayin, Subchronic Reproductive Effects of 6:2 Chlorinated Polyfluorinated Ether Sulfonate (6:2 Cl-Pfaes), an Alternative to PFOS, on Adult Male Mice, Journal of Hazardous Materials, 2018, 358: 256-264
(18) Zhang, Hongxia, Zhou, Xiujuan, Sheng, Nan, Cui, Ruina, Cui, Qianqian, Guo, Hua, Guo, Yong, Sun, Yan, Dai, Jiayin*, Subchronic hepatotoxicity effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), a novel perfluorooctanesulfonate (PFOS) alternative, on adult male mice, Environmental Science & Technology, 2018, 52 (21): 12809-12818
(19) Shi, Guohui, Guo, Hua, Sheng, Nan, Cui, Qianqian, Pan, Yitao, Wang, Jinxing, Guo, Yong, Dai, Jiayin*, Two-generational reproductive toxicity assessment of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B, a novel alternative to perfluorooctane sulfonate) in Zebrafish, Environmental Pollution, 2018, 243: 1517-1527
(20) Cui, Qianqian, Pan, Yitao, Zhang, Hongxia, Sheng, Nan, Dai, Jiayin(*), Elevated concentrations of perfluorohexanesulfonate and other per and polyfluoroalkyl substances in Baiyangdian Lake (China): source characterization and exposure assessment, Environmental Pollution, 2018, 241: 684-691
(21) Cui, Qianqian(#), Pan, Yitao(#), Zhang, Hongxia, Sheng, Nan, Wang, Jianshe, Guo, Yong, Dai, Jiayin(*), Occurrence and tissue distribution of novel ferfluoroether carboxylic and sulfonic acids and legacy per/polyfluoroalkyl substances in Black-Spotted Frog (Pelophylax Nigromaculatus), Environmental Science & Technology, 2018, 52 (3): 982-990 （ESI數據庫（highly cited papers）收錄）
(22) Pan, Yitao(#), Zhang, Hongxia(#), Cui, Qianqian, Sheng, Nan, Yeung, Leo W. Y., Sun, Yan, Guo, Yong, Dai, Jiayin(*), Worldwide distribution of novel perfluoroether carboxylic and sulfonic acids in surface water, Environmental Science & Technology, 2018, 52 (14): 7621-7629 （ESI數據庫（highly cited papers）收錄）
(23) Sheng, Nan, Cui, Ruina, Wang, Jinghua, Guo, Yong, Wang, Jianshe, Dai, Jiayin(*), Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell Line and their binding capacity to human liver fatty acid binding protein, Archives of Toxicology, 2018, 92 (1): 359-369 （ESI數據庫（highly cited papers）收錄）
(24) Sheng, Nan, Pan, Yitao, Guo, Yong, Sun, Yan, Dai, Jiayin(*), Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), a novel perfluorooctanoic acid (PFOA) alternative, on mice, Environmental Science & Technology, 2018, 52 (14): 8005-8015
(25) Shi, Guohui, Xie, Yu, Guo, Yong, Dai, Jiayin(*), 6:2 Fluorotelomer sulfonamide alkylbetaine (6:2 ftab), a novel perfluorooctane sulfonate alternative, induced developmental toxicity in Zebrafish embryos, Aquatic Toxicology, 2018, 195: 24-32
(26) Pan Yitao, Zhang Hongxia, Cui Qianqian, Sheng Nan, Yeung Leo W. Y., Guo Yong, Sun Yan, Dai, Jiayin(*).First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern, Environmental Science & Technology, 2017, 51(17): 9553-9560
(27) Shi Guohui, Cui Qianqian, Pan Yitao, Sheng Nan, Guo Yong, Dai, Jiayin(*).6:2 fluorotelomer carboxylic acid (6:2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis, Aquatic Toxicology, 2017, 190: 53-61
(28) Shi, Guohui, Cui, Qianqian, Pan, Yitao, Sheng, Nan, Sun, Sujie, Guo, Yong, Dai, Jiayin(*), 6:2 Chlorinated polyfluorinated ether sulfonate, a PFOS alternative, induces embryotoxicity and disrupts cardiac development in zebrafish embryos, Aquatic Toxicology, 2017, 185: 67-75 （ESI數據庫（highly cited papers）收錄）
(29) Yan, Shengmin, Zhang, Hongxia, Guo, Xuejiang, Wang, Jianshe, Dai, Jiayin(*), High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver, Archives of Toxicology, 2017, 91 (1): 247-258
(30) Pan, Yitao(#), Zhu, Yingshuang(#), Zheng, Tongzhang, Cui, Qianqian, Buka, Stephen L, Zhang, Bin, Guo, Yong, Xia, Wei, Yeung, Leo W Y, Li, Yuanyuan, Zhou, Aifen, Qiu, Lin, Liu, Hongxiu, Jiang, Minmin, Wu, Chuansha, Xu, Shunqing(*), Dai, Jiayin(*), Novel chlorinated polyfluorinated ether sulfonates and legacy per-/polyfluoroalkyl substances: placental transfer and relationship with serum albumin and glomerular filtration rate, Environmental Science & Technology, 2017, 51 (1): 634-644 （ESI數據庫（highly cited papers）收錄）
榮獲獎勵
中國科意昂4優秀導師獎（2019年度）；
中國科意昂4朱李月華優秀教師獎（2012年度）；